<ACCESSION-NUMBER>0001437749-18-015228 <TYPE>S-8 <PUBLIC-DOCUMENT-COUNT>4 <REFERENCES-429>333-206408 <REFERENCES-429>333-218060 <FILING-DATE>20180810 <DATE-OF-FILING-DATE-CHANGE>20180810 <EFFECTIVENESS-DATE>20180810 <FILER> <COMPANY-DATA> <CONFORMED-NAME>Diffusion Pharmaceuticals Inc. <CIK>0001053691 <ASSIGNED-SIC>2834 <IRS-NUMBER>300645032 <STATE-OF-INCORPORATION>DE <FISCAL-YEAR-END>1231 </COMPANY-DATA> <FILING-VALUES> <FORM-TYPE>S-8 <ACT>33 <FILE-NUMBER>333-226782 <FILM-NUMBER>181009114 </FILING-VALUES> <BUSINESS-ADDRESS> <STREET1>2020 AVON COURT <STREET2>SUITE 4 <CITY>CHARLOTTESVILLE <STATE>VA <ZIP>22902 <PHONE>(434) 220-0718 </BUSINESS-ADDRESS> <MAIL-ADDRESS> <STREET1>2020 AVON COURT <STREET2>SUITE 4 <CITY>CHARLOTTESVILLE <STATE>VA <ZIP>22902 </MAIL-ADDRESS> <FORMER-COMPANY> <FORMER-CONFORMED-NAME>RestorGenex Corp <DATE-CHANGED>20140307 </FORMER-COMPANY> <FORMER-COMPANY> <FORMER-CONFORMED-NAME>Stratus Media Group, Inc <DATE-CHANGED>20080722 </FORMER-COMPANY> <FORMER-COMPANY> <FORMER-CONFORMED-NAME>FERIS INTERNATIONAL, INC. <DATE-CHANGED>20080228 </FORMER-COMPANY> </FILER>